Pomegranate juice has created a stir among medical researchers. There have been multiple clinical trials to explore its benefits in men with prostate cancer, including those who have a rising PSA after
Pomegranate juice has high levels of antioxidants including:
Antioxidants are beneficial because they may prevent the risk of cancer by blocking the actions of free radicals that have been associated with causing cell damage.
Extract of this fruit also contains three anthocyanidins (delphinidin, cyanidin, and pelargonidin) that researchers believe contribute to its antioxidant activity.
In particular, delphinidin has shown promise as a potential cancer-fighting agent in several laboratory studies.
Pomegranate juice: Human studies
An excellent review article by Wang et al provides a great overview of human studies investigaing pomegranate juice (PJ), including:
Hong MY, Seeram NP, Heber D. Pomegranate polyphenols
down-regulate expression of androgen-synthesizing genes in human
prostate cancer cells overexpressing the androgen receptor. J Nutr Biochem. 2008;12:848-55.
Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H.
Pomegranate fruit juice for chemoprevention and chemotherapy of prostate
cancer. Proc Natl Acad Sci USA. 2005;102(41):14813-8.
Noda Y, Kaneyuki T, Mori A, Packer L. Antioxidant activities of
pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin,
and pelargonidin. J Agric Food Chem. 2002;50(1):166–171
Pantuck AJ, Leppert JT, Zomorodian N, et al. Phase II study of
pomegranate juice for men with rising prostate-specific antigen
following surgery or radiation for prostate cancer. Clin Cancer Res. 2006;13:4018-26.
Rettig MB, Heber D, An J, Seeram NP, et al. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Mol Cancer Ther. 2008;7(9):2662-71.
Wang L, Alcon A, Yuan H, Ho J, Li QJ, Martins-Green M. Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. Integr Biol (Camb). 2011 May 19. [Epub ahead of print]
Always consult a medical professional.